Accidental Generalized Vaccinia

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Accidental Infection of Laboratory Worker with Vaccinia

We report the accidental needlestick inoculation of a laboratory worker with vaccinia virus. Although the patient had previously been vaccinated against smallpox, severe lesions appeared on the fingers. Western blot and polymerase chain reaction-restriction fragment length polymorphism were used to analyze the virus recovered from the lesions. The vaccinia virus-specific immunoglobulin G levels...

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Generalized Vaccinia 2 Days after Smallpox Revaccination

To the Editor: Hospital and public health personnel are currently receiving smallpox vaccination in a national effort to increase preparedness for a possible deliberate release of smallpox (1). Generalized vaccinia (GV) is a typically self-limited adverse event following vaccination (incidence 23.4–238.2 cases per million primary vaccinees and 1.2–10.8 cases per million revaccinees) (2,3). We r...

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Generalized vaccinia in patients with pemphigus foliaceus.

ALTHOUGH there are numerous reports of individual cases, only a few papers deal with general aspects of the clinical picture of generalized vaccinia (Tedder, I936; Clark, Seiler, Joe, Gammie, Tait and Jack, I944; Fries, Borne and Barnes, I948). During two outbreaks of generalized vaccinia occurring, after two mass vaccinations, in a hospital for patients with pemphigus foliaceus, some clinical ...

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Vaccinia gangrenosa; the report of a case of prolonged generalized vaccinia.

Serious complications of Jennerian vaccination are extremely rare. The fact, however, that they may occur and endanger life warrants a careful enquiry into any such incident. The more common complications are bacterial infection of the vaccination site and non-specific rashes of erythema multiforme, morbilliform and urticarial types ; except for tetanus, which is becoming exceedingly rare, thes...

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A Study of Generalized Vaccinia in the Chick Embryo

1. Chick embryos infected by the chorio-allantoic route with a bacteria-free strain of vaccinia virus develop a general dissemination of the virus throughout the entire organism with the exception of the central nervous system. 2. Quantitative estimation of the distribution of the virus in the various organs of the infected chick by cutaneous inoculation on the rabbit skin offers no evidence fo...

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ژورنال

عنوان ژورنال: BMJ

سال: 1952

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.4767.1067